History and Philosophy of Science
As a part of the McDonnell initiative at the MBL, we are collaborating with historians and philosophers of science to have better insight and historical context on biological questions. One of the working groups focuses on germline regeneration and is lead by Kate MacCord and B. Duygu Özpolat. Kate and Duygu also work with Beatrice Steinert on history of cell lineage and embryology in Spiralians.
You can find out more about the initiative and working groups here.
Germline Regeneration in Echinoderms
We collaborate with Gary Wessel's lab at Brown University to build on their previous work on sea urchin and sea star germline specification and regeneration. Find out more about the Wessel Lab here.
(Picture: From L-R: Gary Wessel, Thomas Onorato, Gerardo Reyes, Mia Pattillo, Nathalie Oulhen, eStephany Foster, Ingrid Veras, Alice Pieplow, Margherita Perillo, Ruby Schnirman, Ana Fernandez, John Coleman, Will Spurrell, Olivia Akinsunmoye, Duygu Özpolat, Max Spurrell, Emily Kuehn. Missing from photo: Lynae Brayboy, Mamiko Yajima.)
Single Cell Transcriptomics
For understanding cell fate trajectories, and the molecular pathways involved in regeneration, we collaborate with Jordi Solana from Oxford Brooks University on single cell transcriptome experiments.
Fluorescent Dyes and Photosensitizers
We are collaborating with Luke Lavis, HHMI, Janelia for testing and developing dyes to use in cell lineage analyses and selective cell ablation experiments. Our aim is to take advantage of the power of chemistry for investigating regeneration and development, by exploring the use of caged-fluorophore dextrans (photoactivatable), photosensitizers (for inducing cell death), and their combination, in live embryos.