Is the Germline Immortal and Continuous? - Preprint

Kate MacCord and Duygu submitted a review discussing germline immortality and continuity in light of recent research on induced pluripotent stem cells and germline regeneration in several different research organisms.

We have posted a preprint of this manuscript on Zenodo, which you can download from here. If you have any feedback, we would love to hear from you! Post a comment here, or send us an email.

A)  Which component of the germline is immortal and continuous? Stars: points of change. Cells originating from germline (G) in blue, from soma (S) in yellow.  B)  Distribution of germline regeneration across animal phyla. Gray indicates the phylogenetic location of traditional model organisms which cannot regenerate the germline  in vivo  (indicated by "X"). Check marks indicate clades in which there is evidence for germline regeneration.

A) Which component of the germline is immortal and continuous? Stars: points of change. Cells originating from germline (G) in blue, from soma (S) in yellow. B) Distribution of germline regeneration across animal phyla. Gray indicates the phylogenetic location of traditional model organisms which cannot regenerate the germline in vivo (indicated by "X"). Check marks indicate clades in which there is evidence for germline regeneration.